advertisement
Abstract #6459 Published in IGR 3-2
Exploring the potential for subtype-selective muscarinic agonists in glaucoma
Gil D; Spalding T; Kharlamb A; Skjaerbaek N; Uldam A; Trotter C; Li D; Woldemussie E; Wheeler L; Brann MLife Sciences 2001; 68: 2601-2604
Pilocarpine has been used to lower intraocular pressure (IOP) in glaucoma patients for more than 100 years. Since the identification of five muscarinic receptor subtypes, there has been an interest in separating the IOP-lowering effects from the ocular side-effects of pupil constriction and lens accommodation. However, all these actions seem to be mediated by the M3 receptor. A novel muscarinic receptor agonist, AGN 199170, that has no activity on the M3 subtype was compared to pilocarpine in a monkey glaucoma model. This compound lowered IOP, suggesting that muscarinic agonists targeted at muscarinic receptors other than the M3 subtype may be able to selectively lower IOP.
Dr D. Gil, Department of Biological Sciences, Allergan, Inc., Irvine, CA 92612, USA. gil_daniel@allergan.com
Classification:
11.2 Cholinergic drugs (Part of: 11 Medical treatment)
