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Abstract #6468 Published in IGR 3-2
Washout periods for brimonidine 0.2% and latanoprost 0.005%
Stewart WC; Holmes KT; Johnson MAAmerican Journal of Ophthalmology 2001; 131: 798-799
PURPOSE: To evaluate the intraocular pressure (IOP) washout time after discontinuing brimonidine 0.2% twice daily and latanoprost 0.005% once every morning. METHODS: The authors discontinued brimonidine or latanoprost in a masked fashion from primary open-angle glaucoma or ocular hypertensive patients. The IOP was measured twice weekly until patients returned to untreated baseline. RESULTS: In 32 patients, the mean longest eye washout time for brimonidine (n = 15) was 3.3 ± 3.0 weeks and for latanoprost (n = 17) 4.4 ± 3.2 weeks (p = 0.24). In all but one patient, brimonidine returned to baseline by five weeks and latanoprost returned by eight weeks. CONCLUSIONS: After discontinuing latanoprost or brimonidine, a wide variation exists in washout times among individuals, with latanoprost demonstrating a trend towards a longer washout period.
Dr W.C. Stewart, Pharmaceutical Research Corporation, 1639 Tatum Street, Charleston, SC 29412-2646, USA. pr_adm@bellsouth.net
Classification:
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.4 Prostaglandins (Part of: 11 Medical treatment)
