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Abstract #6484 Published in IGR 3-2
Cystoid macular edema associated with topical latanoprost in glaucomatous eyes with a normally functioning blood-ocular barrier
Furuichi M; Chiba T; Abe K; Kogure S; Iijima H; Tsukahara S; Kashiwagi KJournal of Glaucoma 2001; 10: 233-236
PURPOSE: To study prospectively using optical coherence tomography (OCT) whether topical latanoprost induces retinal disorders, such as cystoid macular edema, in patients with glaucoma and a normally functioning blood-ocular barrier. METHODS: Sixty-eight eyes of 38 patients with glaucoma and no history of intraocular surgery, uveitis, or laser trabeculoplasty were studied. Before initiation of latanoprost treatment, and after one, three, and six months of treatment, OCT images were taken, and the following tests were performed: visual acuity examination, fundus ophthalmoscopy, intraocular pressure (IOP) measurement, and fundus color photography. To evaluate retinal thickness in the fovea accurately, OCT scanning was repeated six times, and the smallest value was used as the retinal thickness in the fovea. RESULTS: Latanoprost ophthalmic solution did not influence retinal thickness in the fovea at any investigated time points compared with the time before instillation, and no changes were observed in visual acuity, ophthalmoscopic findings, and fundus photographs. The IOP was reduced significantly at all investigated time points compared with the time before instillation. CONCLUSIONS: It is unlikely that topical latanoprost induces retinal disorders, such as cystoid macular edema, in glaucomatous eyes with a normally functioning blood-ocular barrier.
Dr K. Kashiwagi, Department of Ophthalmology, Yananashi Medical University, 1110 Shimokato, Tamaho Yamanashi 409-3989, Japan. kenjik@res.yamanashi-med.ac.jp
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
