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Abstract #6493 Published in IGR 3-2
Effect of intracameral acetylcholine on latanoprost in preventing ocular hypertension after phacoemulsification and intraocular lens implantation
Lai JSM; Chua JKH; Loo A; Ho SY; Lam DSCJournal of Cataract and Refractive Surgery 2001; 27: 700-705
PURPOSE: To evaluate the effect of intracameral acetylcholine on latanoprost in preventing ocular hypertension in the early period after phacoemulsification with posterior chamber intraocular lens (PC IOL) implantation. METHODS: Patients with uncomplicated cataract undergoing phacoemulsification with PC IOL implantation were included in this prospective, randomized, double-masked, clinical trial. The eyes were randomly assigned to one of four groups based on postoperative application of latanoprost 0.005% alone (group 1), latanoprost 0.005% with intracameral acetylcholine (group 2), intracameral acetylcholine alone (group 3), or no medication (controls, group 4). Intraocular pressure (IOP) was measured three and 24 hours postoperatively. The anterior chamber was examined for the level of cells and flare using slit-lamp biomicroscopy. RESULTS: Three and 24 hours after surgery, the decrease in mean IOP in eyes receiving latanoprost alone was not statistically significantly different from that in control eyes (p > 0.05). Eyes receiving intracameral acetylcholine alone had a significant decrease in mean IOP at three hours (p < 0.05) but not at 24 hours, compared to control eyes (P > 0.05). There were no significant differences in the mean postoperative IOP decrease between eyes receiving latanoprost with intracameral acetylcholine and those receiving intracameral acetylcholine alone (p > 0.05). CONCLUSIONS: A single application of latanoprost did not significantly lower IOP in the first 24 hours after phacoemulsification with PC IOL implantation. Eyes receiving intracameral acetylcholine alone had a significantly greater decrease in IOP than control eyes at three hours, but not at 24 hours. The addition of intracameral acetylcholine to latanoprost did not enhance or reduce latanoprost's IOP-lowering effect.
Dr J.S.M. Lai, Department of Ophthalmology and Visual Sciences, Prince of Wales Hospital, Shatin, Hong Kong, China
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
12.12.3 Phacoemulsification (Part of: 12 Surgical treatment > 12.12 Cataract extraction)
