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Abstract #6509 Published in IGR 3-2
Comparisons of intraocular-pressure-lowering efficacy and side effects of 2% dorzolamide and 1% brinzolamide
Seong GJ; Lee SC; Lee JH; Chu YK; Hong YJOphthalmologica 2001; 215: 188-191
Forty-one healthy volunteers were recruited for a study to compare the intraocular pressure (IOP)-lowering efficacy and side-effects of 2% dorzolamide and 1% brinzolamide. In a randomized, double-blind design, one eye received one drop of 2% dorzolamide and the other one drop of 1% brinzolamide. The IOP and side-effects were evaluated by Goldmann applanation tonometry and slit-lamp biomicroscopy before administration, and three, seven, and 14 days after initial administration of the eye drops. IOP decreased significantly from baseline for both drugs (p < 0.05). However, there were no statistically significant differences between 2% dorzolamide and 1% brinzolamide either before or after eye-drop administration (p > 0.05). The most frequent side-effect was ocular pain in the case of 2% dorzolamide and blurred vision with 1% brinzolamide. The results suggest that 2% dorzolamide and 1% brinzolamide have similar IOP-lowering efficacies with different side-effects.
Dr G.J. Seong, Department of Ophthalmology, Institute of Vision Research, Yonsei University, College of Medicine, Seoul, Korea
Classification:
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)