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Abstract #6542 Published in IGR 3-2
Surface tension controls capsule thickness and collagen orientation in glaucoma shunt devices
Kadri OA; Wilcox MJBiomedical Sciences Instrumentation 2001; 37: 257-262
Surgical implants to shunt aqueous humor from the eyes of glaucoma patients have been used with limited success, due to a build-up of fibrous tissue in the capsule that causes it to fail as a filtration device. Previous studies suggested that fibers orient along the principal stress lines-surface tension on the capsule directs collagen growth in order to strengthen the stretched membrane. The more tension on the capsule, the thicker the fibrous matrix. In the present study, The authors analyze collagen fibril and fiber bundle structure in order to determine whether similar stresses were placed on capsules formed around different implants. They used transmission electron micrographs and light microscopy. Results showed similar structure and collagen fiber bundle densities. This confirmed the authors' previous conclusion that choosing a geometry that reduces surface tension minimizes capsule fibrosis and improves filtration.
Dr O.A. Kadri, Department of Biology, US Air Force Academy, Colorado Springs, CO 80840, USA
Classification:
12.8.2 With tube implant or other drainage devices (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
