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Abstract #6703 Published in IGR 4-1
Color Doppler imaging of retrobulbar hemodynamics after topical carteolol in normal tension glaucoma
Chen MJ; Chou JC; Chiou HJ; Hsu WMZhonghua Yi Xue Za Zhi 2001; 64: 575-580
BACKGROUND: Carteolol is a nonselective adrenergic blocking agent. The aim of this study was to evaluate the effect of topical carteolol on retrobulbar hemodynamics in patients with normal tension glaucoma (NTG). METHODS: Twelve NTG patients received 12 weeks' topical treatment with 2% carteolol. Color Doppler imaging (CDI) was used to evaluate the hemodynamic effects before and after drug therapy. Measurements were obtained from the central retinal artery (CRA), the lateral posterior ciliary artery (LPCA) and the medical posterior ciliary artery (MPCA). From each vessel, peak systolic velocity (PSV), end-diastolic velocity (EDV), resistance index (R1) and Gosling's pulsatility index (PI) were collected and analyzed. RESULTS: After topical carteolol treatment for 12 weeks, mean resistance index reduced significantly from 0.83 to 0.74 in the CRA (p = 0.03), and from 0.74 to 0.68 in the LPCA (p = 0.09). Moreover, mean pulsatility index of the LPCA decreased from 1.45 to 1.26 (p = 0.08). CONCLUSIONS: Twelve weeks of 2% carteolol treatment may decrease the vascular resistance in NTG patients possibly due to the intrinsic sympathomimetic activity (ISA) of carteolol.
Dr. M.J. Chen, Department of Ophthalmology, Taipei Veterans General Hospital, National Yang-Ming University School of Medicine, 201 Second 2 Shih-Pai Road, Taipei 112, Taiwan, China. diany@ms18.hinet.net
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
