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Abstract #6833 Published in IGR 4-1
Allergic contact dermatitis to latanoprost
Jerstad KM; Warshaw EAmerican Journal of Contact Dermat 2002; 13: 39-41
An 85-year-old male with glaucoma presented with a one and a half year history of tearing; red eyes; and pruritic, edematous, eczematous eyelids. Treatment for presumed ocular rosacea and seborrhea was unhelpful. Patch testing to the authors' standard 64 antigens yielded a positive reaction to Balsam of Peru. Notably, benzalkonium chloride, thimerosal, and other preservatives elicited negative reactions. Repeat open application testing elicited positive results to Xalatan (latanoprost) 0.005% ophthalmic solution (Pharmacia & Upjohn, Kalamazoo, MI). A second session of patch tests to ten personal products, in addition to Xalatan 0.005% solution and the Xalatan vehicle (provided by the manufacturer), elicited a strong positive reaction only to the full preparation of Xalatan 0.005% solution. This report describes the first known case of ACD to latanoprost, a new prostaglandin analog that is widely prescribed for treatment of glaucoma.
Dr. K.M. Jerstad, Department of Dermatology, University of Minnesota and the Minneapolis VA, Minneapolis, MN, USA
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
