advertisement
Abstract #6837 Published in IGR 4-1
A double-masked randomized comparison of the efficacy and safety of unoprostone with timolol and betaxolol in patients with primary open-angle glaucoma including pseudoexfoliation glaucoma or ocular hypertension: six-month data
Nordmann JP; Mertz B; Yannoulis NC; Schwenninger C; Kapik B; Shams NAmerican Journal of Ophthalmology 2002; 133: 1-10
PURPOSE: A long-term comparison of the ocular hypotensive efficacy and safety of unoprostone isopropyl 0.15% twice daily with that of timolol maleate 0.5% twice daily and betaxolol HCl 0.5% twice daily.DESIGN: This was a randomized, multicenter, double-masked, active-controlled 24-month clinical trial involving 27 centers in Europe and Israel. METHODS: The study population was composed of patients with primary open-angle glaucoma (including pseudoexfoliation) or ocular hypertension. After washout of antiglaucoma medications, intraocular pressure (IOP) was measured at 0, +2, +8, and +12 hours. Patients were randomized in a 2:1:1 ratio to unoprostone, timolol, or betaxolol. Patients returned for examinations at two and six weeks and three and six months. RESULTS: Five hundred and fifty-six patients were randomized. Each drug produced a clinically and statistically (p Dr. J.P. Nordmann, Hopital National d'Ophtalmologie des Quinze Vingts, Paris, France 11.4 Prostaglandins (Part of: 11 Medical treatment)Classification: