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Abstract #6883 Published in IGR 4-1
Ocular blood flow comparative analysis between betaxolol 0.5% and timolol 0.5%: prospective study
De Figueiredo CR; Suzuki ER Jr; De Figueiredo BP; Batista WDRevista Brasileira de Oftalmologia 2001; 60: 777-780
PURPOSE: To evaluate the effects of betaxolol cloridrate 0.5% (betaxolol) and timolol maleate 0.5% (timolol) in the ocular blood flow using a pulsatile ocular blood flow tonometer (POBF). METHODS: Thirty eyes of 30 patients were observed with POBF tonometer using timolol for two to three months, no medications for two to three months, as well as betaxolol for two to three months. Intraocular pressure (IOP), pulse volume (PV), pulse frequency (PF) and pulsatile ocular blood flow (POBF) were evaluated. RESULTS: First mean values of IOP, PV, PF and POBF were 22.72 mmHg, SD ± 3.33; 5.23 μl, SD ± 2.01; 69.3 bpm =, SD ± 10.66 and 12.50 μl/sec, SD ± 4.30. After timolol, the equivalent values were 18.51 mmHg, SD ± 3.09; 6,68 μl, SD ± 2.40; 62.50 bpm, SD ± 8.68 and 13.84 μl/sec, SD ± 3.71. After betaxolol, the values were 20.02 mmHg. SD ± 3.28; 5.76 μl, SD ± 2.31; 68.66 bpm, SD ± 11.26 and 13.44μl/sec, SD ± 4.16. Both drugs decreased IOP, and increased PV and POBF (p < 0.01). Timolol showed a higher decrease of IOP and increase of PV (p < 0.01). No significative difference in POBF between medications (p = 0.27). CONCLUSIONS: All drugs have good effects in hemodynamics and IOP. This research showed timolol to be more efficient than betaxolol in IOP and PV control.LA: Portuguese
Dr. C.R. De Figueiredo, Rua Padre Rolim, 541, Belo Horizonte-MG-CEP: 30130-090, Brazil
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
