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Abstract #8037 Published in IGR 4-3
Long-term follow-up of initially successful trabeculectomy with 5-fluorouracil injections
Suzuki R; Dickens CJ; Iwach AG; Hoskins Jr HD; Hetherington Jr J; Juster RP; Wong PC; Klufas MT; Leong CJ; Nguyen NOphthalmology 2002; 109: 1921-1924
PURPOSE: To study the long-term results (one to 14 years) of trabeculectomies with 5-fluorouracil injections that were successful at one year. DESIGN: A retrospective noncomparative case series. INTERVENTION/PARTICIPANTS: The authors identified 87 patients (87 eyes) who had trabeculectomies with 5-fluorouracil injections from 1984-1989 that were successful at one year and had a follow-up range of 1.0-14.7 years (mean, 8.1, standard deviation of 4.4 years). All patients had previously failed glaucoma surgery (66.7%), cataract surgery (47.1%), or other diagnoses making them at high risk for failure. MAIN OUTCOME MEASURES: Successful control of intraocular pressure (IOP) was defined as IOP less than 21 mmHg or a reduction of 33% if preoperative pressure was less than 21 mmHg. Statistical analysis was performed using Kaplan-Meier life table analysis. RESULTS: If an eye is considered successful by IOP at one year, the probability of successful control is 61% at five years, 44% at ten years, and 41% at 14 years. CONCLUSIONS: Despite successful IOP control at one year, trabeculectomies with 5-fluorouracil injections show a continual loss of IOP control over time.
R. Suzuki, MD, Glaucoma Research and Education Group, San Francisco, CA 94102, USA
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
