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Abstract #8040 Published in IGR 4-3
Anti-inflammatory fibrosis suppression in threatened trabeculectomy bleb failure produces good long term control of intraocular pressure without risk of sight threatening complications
Fuller JR; Bevin TH; Molteno ACB; Vote BJT; Herbison PBritish Journal of Ophthalmology 2002; 86: 1352-1354
AIMS: To determine the long-term outcome of systemic anti-inflammatory fibrosis suppression in cases of threatened trabeculectomy bleb failure in open-angle glaucoma. METHODS: This prospective non-comparative case series followed 77 eyes of 63 patients which showed signs of threatened early bleb failure and were treated with oral anti-inflammatory fibrosis suppression of prednisone, a non-steroidal anti-inflammatory agent, and colchicine taken for a mean period of six weeks, in addition to standard postoperative topical treatment, for a mean follow-up of six years. RESULTS: Trabeculectomy with anti-inflammatory fibrosis suppression controlled the IOP at 21 mmHg with a probability of 0.91 (95% CI: 0.81-1.0) at eight years and 0.89 (95% CI: 0.56-1.1) at 12 years. There were no reported cases of endophthalmitis, hypotonous maculopathy, late bleb leak, or serious systemic side-effects. CONCLUSION: Anti-inflammatory fibrosis suppression provided good control of bleb fibrosis without risk of sight threatening complications in a patient group at high risk of bleb failure.
ACB Molteno, MD, Department of Ophthalmology, University of Otago Medical School, PO Box 913, Dunedin, New Zealand. georgi.bond@healthotago.co.nz
Classification:
12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
