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Abstract #8144 Published in IGR 4-3
Cognitive evoked potential in primary wide angle glaucoma
Zarazaga I; Cristobal JA; Broto MA; Valdizan-Uson JR; Brualla-Coll J; Garcia-Campayo JRevista de Neurologia 2002; 34: 801-807
INTRODUCTION: Primary wide-angle glaucoma (PWAG) is the commonest form of this disorder. It is initially asymptomatic, until there has been considerable visual field loss. Personality changes have been described in patients with wide-angle glaucoma, with a significant percentage developing dementia or a tendency to react defensively. The P300 endogenous evoked potential is related to memory/attention to work. OBJECTIVE: To evaluate, in PWAG, the probable occurrence of a disorder of visual processing due to alteration in the attention/working memory and its neuronal network, using the P300 visual cognitive evoked potential in correlation with Lobo's cognitive mini-examination (CME). PATIENTS AND METHODS: The authors selected 68 patients with PWAG and 68 controls, of both sexes, aged between 50 and 65 years. CME was carried out after obtaining clinical history, and then an electroretinogram, visual evoked potential using the alternating dameres (ERGd and VEPd) and P300 potential (passive odd-ball). Statistical analysis was performed using the t test, one-way ANOVA, and discriminating analysis. RESULTS: The amplitude on ERGd and latency on VEPd were significantly altered. Patients with glaucoma had lower scores on CME. Regarding the P300 wave, latency was the most significant parameter, while the amplitude and site were less well defined. CONCLUSIONS: In PWAG, a process of visual cognitive dysfunction occurs and affects memory/attention so that it works in a way which is not only due to the peripheral visual effect. LA: Spanish
J.R. Valdizan-Uson, MD, Servicio de Neurofisiol. Clinica, Hospital Universitario Miguel Servet, Paseo Isabel la Catolica, 1, E-50009 Zaragoza, Spain. josevaldizan@terra.es
Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)