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Abstract #8162 Published in IGR 4-3
Postural variation in intraocular pressure in primary chronic autonomic failure
Dumskyj MJ; Mathias CJ; Dore CJ; Bleasdale BK; Kohner EMJournal of Neurology 2002; 249: 712-718
Patients with syndromes of generalized autonomic failure often have extreme posture-related lability of blood pressure, with both orthostatic hypotension and recumbent hypertension. Whether these changes influence intraocular pressure (IOP) is not known. Mean arterial pressure (MAP) and IOP were measured in response to variations in posture between +45° and -20° in eight normal subjects and nine subjects with primary generalized chronic autonomic failure (AF). With postural change, normal subjects showed minimal change in MAP (p = 0.6) and small but significant changes in IOP (p < 0.001). Subjects with AF showed large and significant changes in both MAP (p < 0.001) and IOP (p < 0.001). Two AF subjects had raised IOP when recumbent, despite normal IOP at +45°. There was significant covariance of MAP and IOP (p < 0.001 overall, p = 0.004 in normal subjects, p = 0.006 in AF subjects). However, individually, those patients with large changes in IOP could not be predicted from changes in MAP. These data show that patients with autonomic failure are subject to large posture-related changes in IOP. These appear to be related to the large posture-induced changes in systemic blood pressure which occur in these patients.
M.J. Dumskyj, MD, Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George's Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK
Classification:
6.1 Intraocular pressure measurement; factors affecting IOP (Part of: 6 Clinical examination methods)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
