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Abstract #8185 Published in IGR 4-3
Detection of connective tissue growth factor in human aqueous humor
Van Setten G; Blalock TD; Grotendorst G; Schultz GSOphthalmic Research 2002; 34: 306-308
PURPOSE: Connective tissue growth factor (CTGF) has been shown to be substantially involved in various processes of fibrosis. The authors investigated if CTGF is present in aqueous humor (AH). METHODS: Samples from AH were collected from ten volunteers during cataract surgery. Specific ELISA analysis was performed with goat IGG against human CTGF. RESULTS: CTGF was above the detection limit of the assay in 80% of the samples. The concentration of CTGF in the anterior chamber fluid was 1.24 ± (SD) 0.26 ng/ml. CONCLUSIONS: CTGF is present in a majority of AH samples, possibly representing a constant component in this fluid. The origin and physiological importance of CTGF is yet unclear. The involvement of CTGF in processes of intraocular fibrosis and wound healing is possible.
G. van Setten, MD, Karolinska Institutet, St Eriks Eye Clinic, Polhemsgatan 50, S-11282 Stockholm, Sweden. g.van.setten@sankterik.se
Classification:
2.6 Aqueous humor dynamics (Part of: 2 Anatomical structures in glaucoma)