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Abstract #8261 Published in IGR 4-3
Effect of treatment by medicine or surgery on intraocular pressure and pulsatile ocular blood flow in normal-pressure glaucoma
Poinoosawmy D; Indar A; Bunce C; Garway-Heath DF; Hitchings RAGraefe's Archive for Clinical and Experimental Ophthalmology 2002; 240: 721-726
PURPOSE: To study the effect of trabeculectomy and monotherapy with topical betaxolol, brimonidine and latanoprost on intraocular pressure (IOP) and pulsatile ocular blood flow (POBF) in patients with normal-pressure glaucoma (NPG). METHODS: In this retrospective study, NPG patients attending the glaucoma research unit at Moorfields Eye Hospital were reviewed. Patients treated by surgery or topical medication (betaxolol, brimonidine or latanoprost) who had pre- and post-treatment IOP and POBF measurements, were studied. For those patients who were having treatment to both eyes, one eye was selected at random for analysis. RESULTS: A total of 147 patients was reviewed. Forty-three eyes were receiving betaxolol 0.5%, 58 latanoprost 0.005%, 23 brimonidine 0.2%, and 23 eyes had undergone trabeculectomy surgery. There were more female than male patients in all four groups, and the groups were similar with regard to age. Pre-treatment IOP and POBF values were similar among the groups (p = 0.27, p = 0.08, respectively). Post-treatment IOP values tended to be lower than pretreatment values for all four groups. All groups had an increased POBF, except for betaxolol, where POBF decreased. CONCLUSIONS: Patients treated by trabeculectomy and those receiving topical latanoprost and brimonidine had lower IOP and higher POBF following treatment. The betaxolol-treated group, despite a slight decrease in IOP, had a decreased POBF. Lowering IOP by treatment may not necessarily be associated with an increase in POBF.
R.A. Hitchings, MD, Glaucoma Research Unit, Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK. roger.hitchings@moorfields.nhs.uk
Classification:
11.7 Treatment of bloodflow (Part of: 11 Medical treatment)