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Abstract #8265 Published in IGR 4-3
Quantitative analysis of eyelash lengthening following topical latanoprost therapy
Sugimoto M; Sugimoto M.; Uji YCanadian Journal of Ophthalmology 2002; 37: 342-345
BACKGROUND: There have been several reports, mostly qualitative, of ocular side-effects of latanoprost, including lengthening of the eyelashes. The authors investigated changes in eyelash length in patients receiving topically-administered latanoprost. METHODS: Seventeen patients (11 males and six females, aged 63-80 years) with glaucoma or ocular hypertension were treated with latanoprost (one drop to one eye daily at bedtime). All had dark brown irises. At the start of treatment and after two, six, and ten weeks of treatment, a single eyelash was removed from the center of the upper eyelid of the treated and fellow (control) eyes, and measured. Adverse events (defined as any undesirable event occurring in a subject, regardless of whether it was considered to be related to the latanoprost treatment) were carefully monitored. At each examination, patients were asked whether they had any ocular or systemic symptoms. RESULTS: For the eyes treated with latanoprost, the mean eyelash length (and SD) was 5.8 mm (0.7 mm) at baseline, 6.5 mm (0.6 mm) at two weeks, 6.5 mm (0.9 mm) at six weeks, and 6.6 mm (0.7 mm) at ten weeks (p < 0.001 for all differences from baseline). The corresponding values for the untreated eyes were 5.7 mm (0.7 mm), 5.8 mm (0.7 mm), 5.9 mm (0.7 mm), and 5.6 mm (0.7 mm), respectively; all differences were nonsignificant. INTERPRETATION: latanoprost significantly increases eyelash length.
M. Sugimoto, MD, Department of Ophthalmology, Mie University School of Medicine, 2-174 Edobashi, Tsu-city, Mie 514-8507, Japan. sugmochi@aqua.ocn.ne.jp
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)