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Abstract #8301 Published in IGR 4-3

Topically administered CB²-receptor agonist, JWH-133, does not decrease intraocular pressure (IOP) in normotensive rabbits

Laine K; Jarvinen K; Jarvinen T
Life Sciences 2003; 72: 837-842

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Recent intraocular pressure (IOP) and receptor localization studies suggest that the IOP effects of cannabinoids are mediated via ocular CB¹ receptors. However, it is not yet known whether CB² receptor agonists decrease IOP. In this study, the IOP-lowering effects of the CB² receptor agonist JWH-133 were studied in normotensive rabbits, and compared with CP55,940. JWH-133 and CP55,940 were dissolved in aqueous hydroxypropyl-beta-cyclodextrin (HP-beta-CD) solutions and propylene glycol. The eye drops (25 μl) were administered unilaterally to the rabbit eye, and IOPs were measured at fixed time intervals. JWH-133, dissolved in either HP-beta-CD (doses = 10 and 25 μg) or propylene glycol (dose = 62.5 μg), did not have any effect on IOP when compared to vehicle treatments. In contrast, CP55,940 formulated in HP-beta-CD (doses = 25 and 62.5 μg) or propylene glycol (dose = 62.5 μg) significantly reduced IOP compared to vehicle treatments. The results suggest that topically administered CB² receptor agonist, JWH-133, does not decrease IOP in normotensive rabbits at the doses and formulations used, and thus, CB² receptor agonists may not be useful as cannabinoid-based IOP-lowering therapeutics.

K. Laine, MD, Department of Pharmaceutical Chemistry, University of Kuopio, POB 1627, Finland. krista.laine@uku.fi

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Classification:

11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)

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