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Abstract #8318 Published in IGR 4-3
Effect of brimonidine on patients undergoing uncontrolled IOP with beta-blockers
Taverniti L; Donati S; Di-Staso S; Arrico L; Giuffre I; Recupero SMActa Ophthalmologica Scandinavica, Supplement 2002; 80: 54
The authors evaluated the effect of the replacement of β-blockers with brimonidine drops in patients taking β-blockers only or with dorzolamide, with an intraocular pressure (IOP) > 20 mmHg. The study was divided into two sections: one group treated with brimonidine b.i.d. (23 patients) and the other treated with brimonidine + dorzolamide b.i.d. (17 patients). The effect of the substitution showed after 90 days of treatment with a reduction of 8.59 ± 1.2 mmHg (p < 0.001) in the first group and 6.1 ± 1.7 mmHg (p < 0.001) in the second group. Three patients in the first group and four in the second group presented with minor adverse effects, which did not justify discontinuation of treatment. Brimonidine was an effective treatment as a substitute for β-blockers only when associated with dorzolamide.
L. Taverniti, MD, Eye Clinic, 'La Sapienza' University of Rome, Rome, Italy
Classification:
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
