advertisement
Abstract #8439 Published in IGR 5-1
Macular thickness changes in glaucomatous optic neuropathy detected using optical coherence tomography
Greenfield DS; Bagga H; Knighton RWArchives of Ophthalmology 2003; 121: 41-46
OBJECTIVE: To correlate macular thickness and retinal nerve fiber layer (RNFL) thickness in normal and glaucomatous eyes using optical coherence tomography. METHODS: Complete examination, automated achromatic perimetry, and optical coherence tomography of the peripapillary RNFL and macula were performed. Exclusion criteria were visual acuity of less than 20/40, diseases other than glaucoma, and unreliable automated achromatic perimetry. Macular thickness measurements were generated using 6 radial optical coherence tomographic scans (5.9 mm) centered on the fovea, and mean and quadrantic macular thickness values were calculated. RESULTS: Fifty-nine eyes of 59 patients (29 normal and 30 glaucomatous) were enrolled (mean ± SD age, 56.7 ± 20.3 years; range, 20-91 years). All eyes with glaucoma had associated visual field loss (mean ± SD mean defect, -8.4 ± 5.8 dB). Mean macular thickness was significantly associated with visual field mean defect (r2 = 0.47; p < 0.001), pattern standard deviation (r2 = 0.32; p < 0.001), and mean RNFL thickness (r2 = 0.38; p < 0.001). In glaucomatous eyes with visual field loss localized to one hemifield (n = 11), mean ± SD macular thickness in the quadrant associated with the field defect (277 ± 28 μm) was significantly less (p = 0.005) than in the unaffected quadrant (286 ± 27 μm). Mean RNFL thickness in the affected quadrant (89 ± 53 μm) was significantly thinner (p = 0.009) than in the unaffected quadrant (121 ± 39 μm). MAIN OUTCOME MEASURES: Mean total and quadrantic macular and RNFL thickness measurements. CONCLUSIONS: Macular thickness changes are well correlated with changes in visual function and RNFL structure in glaucoma and may be a surrogate indicator of retinal ganglion cell loss.
Dr. D.S. Greenfield, Department of Ophthalmology, University of Miami School of Medicine, Bascom Palmer Eye Institute, 7108 Fairway Dr, Suite 340, Palm Beach Gardens, FL 33418, USA. dgreenfield@med.miami.edu
Classification:
6.9.2 Optical coherence tomography (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
