advertisement
Abstract #8931 Published in IGR 5-2
Multifunctional drugs for endothelial dysfunction in diabetes and glaucoma
Wood PLIdrugs 2003; 6: 360-367
Endothelial dysfunction is a multifactorial term in that it encompasses a number of complex biochemical alterations in the ability of endothelial cells to perform their normal physiological function. These alterations are generally initiated by increased oxidative stress leading to pathological alterations in the cellular balance of mediators produced by endothelial cells. The key mediators include nitric oxide (NO), superoxide and endothelin. This review presents the current status of our knowledge of endothelial dysfunction in diabetes and in glaucoma and presents the case for evaluation of multifunctional drugs in these diseases.
Dr. P.L. Wood, OxoN Medica Inc, 385 Oyster Point Boulevard, Suite 9A, South San Francisco, CA 94080, USA. pwood@oxonmedica.com
Classification:
11.1 General management, indication (Part of: 11 Medical treatment)
