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Abstract #8943 Published in IGR 5-2
The free amino acids and the aqueous humor pH after antiglaucomatics in vitro
Veselovsky J; Olah Z; Vesela A; Gressnerova SBratisl Lek Listy 2003; 104: 14-18
The authors present a comparison of previous results on the influence of free amino acids on the aqueous humor of rabbits and humans on aqueous humor pH in vitro. Four clinically used antiglaucomatics were added (2% trusopt, pH 5.33; 0.005% xalatan, pH 6.4; 0.5% timoptol, pH 6.80, and 1% pilocarpine, pH 5.87) into acquired aqueous humor of rabbits (pH 7.59) and humans (pH 7.11 ± 0.11). After the instillation of aqueous humor pH, there was an immediate decrease towards acid levels. pH changes after timoptol, xalatan and pilocarpine showed a similar time pattern and after return to baseline values, the pH shifted to alkaline levels. In case of trusopt instillation, the pH value reached the aqueous humor baseline after 240 minutes. Almost no pH changes were recorded from 240 minutes to 24 hours after all tested antiglaucomatics. From the point of view of speed of activity and effectivity depending on time required to reach the initial value of aqueous humor pH, the situation is as follows: pilocarpine > timoptol > xalatan > trusopt. Comparing these results, the effect of antiglaucomatics is connected with different compositions and also with the shift of aqueous humor pH towards a slightly alkaline level (similar effect in rabbits and humans). The results presented here are theoretical, but are also a practical contribution to the treatment of glaucoma.
Dr. J. Veselovsky, Institute of Animal Physiology and Ethology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia. veselovsky@fnf.uniba.sk
Classification:
11.2 Cholinergic drugs (Part of: 11 Medical treatment)
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.4 Prostaglandins (Part of: 11 Medical treatment)