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Abstract #9089 Published in IGR 5-2
Quantification of retinal nerve fiber defects in glaucoma: three-dimensional analysis by Heidelberg retina tomograph
Miyake K; Uchida H; Sugiyama K; Yamamoto T; Kitazawa Y; Shinohara HJapanese Journal of Ophthalmology 2003; 47: 347-350
PURPOSE: To describe a new method of quantifying retinal nerve fiber layer defects (NFLD) in glaucomatous eyes using the Heldelberg retina tomograph (HRT). METHODS: Mean tomographic images including the optic disc and peripapillary area were constructed using HRT. An image field of 15 x 15° or 20 x 20° was used for the NFLD analysis. Data on nerve fiber layer thickness were collected and further analyzed circumferentially across the NFLD at a position 500 μm away from the optic disc margin. The authors studied 31 patients with early to moderate open-angle glaucoma, i.e., with visual field defects appearing earlier than stage 3 of the modified Aulhorn-Greve classification. They determined width (W), maximum depth (D), and cross-sectional area of the NFLD (A), and identified correlations between these parameters and the visual field indices from Humphrey visual field tests, mean deviation (MD), and corrected pattern standard deviation (CPSD). RESULTS: NFLD parameters could be obtained from 20 of 31 eyes (65%). There was a statistically significant correlation between D and A parameters, and between these parameters and the maximum depression threshold in the corresponding visual field. No significant correlation was found between NFLD parameters, global visual field indices (MD, CPSD), and mean value of total deviation (TD) in the corresponding hemifield visual field. CONCLUSIONS: A cross-sectional NFLD image can be obtained using HRT. In the three NFLD parameters, D and area under the surface (A) correlated well with the visual field threshold.
Dr. K. Miyake, Department of Ophthalmology, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan. Kmgifu@aol.com
Classification:
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
