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Abstract #9120 Published in IGR 5-2
The activity of superoxide dismutase and glutathione peroxidase in the humor aqueous of patients with the primary open-angle glaucoma
Jovanovic P; Dordevic V; Zlatanovic G; Zvezdanovic L; Cosic VJugoslovenska Medicinska Biokemija 2003; 22: 165-168
Glaucoma is an optical neuropathy characterized by excavation of the optic disc, visual field defects and, in most cases, higher intraocular pressure. In the pathogenesis of primary open-angle glaucoma, a significant role is given to oxidative stress. The goal of this study was to determine the activity of antioxidative enzymes (superoxide dismutase, SOD and glutathione peroxidase, GPX) in humor aquosus in patients with primary open-angle glaucoma (POAG) and with primary angle-closure glaucoma (PACG; control group) before and after therapy with exogenous antioxidants. The activity of the examined enzymes in the aqueous humor of patients with POAG was significantly higher than that of patients with PACG (p < 0.001). Exogenous antioxidants diminish the concentration of free radicals, resulting in a decrease in antioxidative enzyme activity, and point to their possible use in glaucoma therapy (as a complementary therapy). LA: Serbian
Dr. P. Jovanovic, Klinika za Ocne Bolesti KC Nis, Brace Taskovica 48, 18000 Nis, Yugoslavia
Classification:
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)