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Abstract #9236 Published in IGR 5-2
Therapy of normal tension glaucoma: effect of brinzolamide on ocular haemodynamics
Klemm M; Zeitz O; Reuss J; Matthiessen ET; Richard GKlinische Monatsblätter für Augenheilkunde 2003; 330-333
BACKGROUND: Altered ocular perfusion plays a role in the pathophysiology of normal tension glaucoma. Dorzolamide, a locally applied inhibitor of carbonic anhydrase, is thought to increase ocular blood flow. Less data are available regarding the influence exercised on ocular perfusion by brinzolamide, another and different, locally administered, inhibitor of carbonic anhydrase. PATIENTS AND METHODS: Fifteen eyes of eight normal-tension glaucoma patients were subjected to color Doppler imaging and Langham-OBF (LOBF) before and during a therapy for three to five weeks with brinzolamide. RESULTS: Brinzolamide reduces intraocular pressure from 15.8 ± 0.9 to 12.6 ± 0.9 mmHg (n = 15; p < 0.05). Systolic as well as diastolic blood flow velocities, resistive (RI) and pulsatility index (PI), measured by CDI, remained unchanged in the presence of brinzolamide. LOBF values are also not influenced by brinzolamide (1014 ± 115 before versus 1113 ± 178 μl under therapy; n = 15; n.s.). DISCUSSION: Brinzolamide does not exercise any impact on ocular hemodynamics. This is different from the properties of dorzolamide that had been reported previously. LA: German
Dr. M. Klemm, Universitätsklinikum Hamburg-Eppendorf, Klinik und Poliklinik für Augenheilkunde, Hamburg, Germany
Classification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
11.7 Treatment of bloodflow (Part of: 11 Medical treatment)
