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Published studies agree that transient intraocular pressure (IOP) spikes are common after intravitreal injections of anti-vascular endothelial growth factor (VEGF) agents. Currently, there is no standard of care guiding if and when to prevent these IOP spikes. Furthermore, there are challenges in determining the impact of post-injection IOP elevation on the health of the retinal ganglion cells, particularly given the often-existing comorbidities of retinal and glaucoma pathology. This review highlights the current literature regarding both acute and chronic post-injection IOP elevations and discusses management of post-injection IOP elevation, especially in patients at high risk for glaucomatous damage.
John Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Aurora, CO.
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