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Abstract #9777 Published in IGR 5-3

The effect of blood glucose regulation on retinal nerve fiber layer thickness in diabetic patients

Lonneville YH; Özdek EC; Önol M; Yetkin I; Gürelik G; Hasanreisolu B
Ophthalmologica 2003; 217: 347-350


PURPOSE: To evaluate the effect of blood glucose (BG) regulation on the retinal nerve fiber layer (RNFL) in diabetic patients using a scanning laser polarimeter (NFA-GDx). METHODS: The authors prospectively assessed RNFL thickness in diabetic patients and an age-matched control group. Patients without diabetic retinopathy, with BG >250 mg/dl, HbA1c >8%, fructosamine >285 μmol/l and triglyceride >200 mg/dl were included in the study. RNFL assessment was performed before and after metabolic regulation of diabetes. Symmetry, superior maximum, ellipse modulation and the average thickness variables of NFA-GDx were used for the assessment. Mann-Whitney U and Wilcoxon tests were used for the statistical analysis. RESULTS: A total of 40 diabetic patients were included in the study and a repeat RNFL examination could be performed in 22 of them following regulation of BG levels. None of the GDx variables were significantly different between pre- and postregulation measurements (p > 0.05, Wilcoxon test). The mean superior maximum, ellipse modulation and average thickness values of the diabetic group were significantly lower than the control group (p < 0.05, Mann-Whitney U-test). CONCLUSIONS: Poor metabolic control of diabetes mellitus adversely affects the thickness of RNFL and this effect does not seem to be acute since it was not reversed by short-term BG regulation. This issue needs to be kept in mind when assessing glaucomatous progress in diabetic patients.

Dr. E.C. Özdek, Isci Bloklar mah. 31. Cad., Ozgur Anl sit. A-Blok No: 30, 100.YIL, TR-06530 Ankara, Turkey. ozdek@ttnet.net.tr


Classification:

6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)



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