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Abstract #9778 Published in IGR 5-3
Effect of laser in situ keratomileusis on optic nerve head topography and retinal nerve fiber layer thickness
Whitson JT; McCulley JP; Cavanagh HD; Song J; Bowman RW; Hertzog LJournal of Cataract and Refractive Surgery 2003; 29: 2302-2305
PURPOSE: To determine whether laser in situ keratomileusis (LASIK) produces significant changes in optic nerve head (ONH) topography and retinal nerve fiber layer (RNFL) thickness as measured by the Heidelberg Retina Tomograph (HRT), and to evaluate the potential neuroprotective effect of topical betaxolol on these changes. SETTING: Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas. METHODS: In this prospective randomized double-masked comparative case series, 34 patients having LASIK for myopia were randomly assigned to receive topical betaxolol 0.5% solution or placebo twice a day for two days before the procedure and seven days after the procedure. Preoperative and postoperative (one week and one and three months) images were made with the HRT. Four HRT parameters (rim area, rim volume, mean RNFL thickness, and cup shape measure) were analyzed in a masked fashion. Student's paired t test was used for statistical analysis. RESULTS: No significant changes from baseline occurred in any HRT parameter in either patient group or when the patients were evaluated as a single group. CONCLUSIONS: Laser in situ keratomileusis did not adversely affect ONH morphology or RNFL thickness as measured by HRT. Since no neural damage was detected, the potential neuroprotective effect of betaxolol could not be evaluated.
Dr. J.T. Whitson, Department of Ophthalmology, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, , Dallas, TX 75390-9057, USA
Classification:
6.9.1 Laser scanning (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
8.4 Refractive surgical procedures (Part of: 8 Refractive errors in relation to glaucoma)
