advertisement
Abstract #9938 Published in IGR 5-3
The effect of Erigeron Breviscapus (Vant) Hand-Mazz on ocular blood flow in glaucomatous eyes
Ye C; Jiang YChinese Ophthalmic Research 2003; 21: 527-530
OBJECTIVE: To evaluate the effect of Erigeron Breviscapus (vant) Hand-Mazz (EBHM) on the ocular blood flow in glaucomatous eyes with the intraocular pressure controlled. METHODS: Forty-two patients (eyes) with moderate and late glaucoma were enrolled in a prospective and double-masked clinical trial and randomly assigned to the EBHM or age-matched placebo control group. EBHM and placebo tablets were orally taken (#2 t. i. d.) respectively over six months. The effectiveness of EBHM on the ocular blood flow was assessed by color Doppler imaging system (CDI) at the first and final visits. RESULTS: IOP was 14.30 ± 2.48 and 14.44 ± 2.02 mmHg for the EBHM and control groups, respectively (p = 0.841) during the six months. After the six months, ocular peak systolic velocity (PSV) and end diastolic velocity (EDV) of ophthalmic arteries (OA), central retinal arteries (CRA) and short posterior ciliary arteries (SPCAs) remained unchanged in both groups. Only the resistive index (RI) in OA decreased 0.059 in the EBHM group (p = 0.009). EBHM did not show any effect on arterial pressure, optic nerve head perfusion pressure or heart rate. CONCLUSIONS: Although EBHM can reduce the RI of OA, it cannot directly demonstrate that EBHM improves the blood flow of the optic nerve head. More advanced technique should be applied to study the effect of EBHM on ocular blood flow in glaucoma. LA: Chinese
Dr. C. Ye, Department of Ophthalmology, Second Xiangya Hospital, Central South University, Changsha 410011, China
Classification:
11.7 Treatment of bloodflow (Part of: 11 Medical treatment)
