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1 General aspects (0)   1.1 Epidemiology (6)   1.2 Population genetics (1)   1.3 Pathogenesis (0)   1.4 Quality of life (1)   1.5 Glaucomas as cause of blindness (4)   1.6 Prevention and screening (2) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (1)   2.2 Cornea (2)   2.3 Sclera (0)   2.4 Anterior chamber angle (2)   2.5 Meshwork (1)     2.5.1 Trabecular meshwork (16)     2.5.2 Schlemms canal (0)     2.5.3 Scleral outlet channels (0)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (2)     2.6.2 Outflow (2)       2.6.2.1 Trabecular meshwork (2)       2.6.2.2 Uveoscleral (1)     2.6.3 Compostion (0)   2.7 Episcleral veins and venous pressure (0)   2.8 Iris (0)   2.9 Ciliary body (1)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (1)   2.13 Retina and retinal nerve fibre layer (8)   2.14 Optic disc (11)   2.15 Optic nerve (1)   2.16 Chiasma and retrochiasmal central nervous system (0)   2.17 Stem cells (0)   2.20 Other (1) 3 Laboratory methods (0)   3.1 Microscopy (0)   3.2 Electron microscopy (0)   3.3 Immunohistochemistry (11)   3.4 Molecular genetics (3)     3.4.1 Linkage studies (6)     3.4.2 Gene studies (7)   3.5 Molecular biology incl. 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Abstract #9999 Published in IGR 5-3

Effects of octreotide acetate and amniotic membrane on wound healing in experimental glaucoma surgery

Demir T; Turgut B; Celiker U; Ozercan I; Ulas F; Akyol N
Documenta Ophthalmologica 2003; 107: 87-92

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Wound healing affects the success of glaucoma filtering surgery. Antimetabolites and antifibrotic agents are used in the modulation of surgical trauma. This study is performed to evaluate the effects of amniotic membrane and octreotide acetate on wound healing . Thirty pigmented rabbits were divided into three groups of ten animals each. Trabeculectomy and topical postoperative prednisolone sodium phosphate four times daily for seven days were applied to one eye of all the rabbits. After trabeculectomy, octreotide 10 μg three times daily applied topically to the octreotide group for 14 days and amniotic membrane transplantation was performed by suturing amniotic membrane between scleral flap and sclera to the amniotic membrane group. The operated eyes of the rabbits were enucleated on the 14th day of the operation and histopathological specimens were obtained from the bleb sites and they were evaluated by light microscope. Fibroblast and macrophage number per cm² were counted and the average values were calculated. Compared to the control group, the fibroblasts and macrophages significantly decreased in the other two groups (p < 0.0001, p < 0.0001, respectively). The mean number of fibroblasts was lower than those of the control and amniotic membrane groups (p < 0.0001, p < 0.0001, respectively). Similarly, the mean macrophage number was significantly lower in the octreotide group compared to the control and amniotic membrane groups (p < 0.0001, p < 0.01, respectively). Octreotide administration and amniotic membrane transplantation might be alternative treatments in modulating the wound healing after trabeculectomy.

Dr. T. Demir, Department of Ophthalmology, Firat University Medical School, Elazig, Turkey

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Classification:

12.8.10 Woundhealing antifibrosis (Part of: 12 Surgical treatment > 12.8 Filtering surgery)

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