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Abstract #45520 Published in IGR 13-2

Contact transcleral photodynamic cyclo-suppression in human eyes: a feasibility study

Charisis SK; Detorakis ET; Vitanova VS; Panteleontidis VA; Kounis GA; Tsilimbaris MK
Canadian Journal of Ophthalmology 2010; 46: 196-198


Objective: To evaluate the safety and efficacy of contact transcleral ciliary body photodynamic treatment (CB-PDT) with verteporfin in human eyes. Design: Prospective interventional case series. Participants: Five glaucomatous blind eyes of 5 patients. Methods: Verteporfin (6 mg/m2) was infused in bolus and then the ciliary body was irradiated transclerally with a fibre optic device. Twelve spots were placed 360u and 0.5 mm behind the sclerocorneal limbus. Laser power was 80 mW and irradiation time was 3 minutes. Results: The average intraocular pressure reduction was 30% after the first month and remained below pre-treatment levels throughout a 3-month follow-up. No serious adverse events were reported. Conclusions: CB-PDT for refractory glaucoma was safe and efficient in human eyes; larger studies are required to evaluate its possible clinical role.

University Hospital of Heraklion, Department of Ophthalmology, Crete, Greece.


Classification:

12.10 Cyclodestruction (Part of: 12 Surgical treatment)



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