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Abstract #21765 Published in IGR 10-3

Anterior chamber angle measurement with anterior segment optical coherence tomography: a comparison between slit lamp OCT and Visante OCT

Leung CK; Li H; Weinreb RN; Liu J; Cheung CY; Lai RY; Pang CP; Lam DS
Investigative Ophthalmology and Visual Science 2008; 49: 3469-3474

See also comment(s) by Lisandro Sakata & Tin Aung •

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PURPOSE: To compare anterior chamber angle measurements obtained from two anterior segment optical coherence tomography (OCT) instruments and to evaluate their agreements and interobserver reproducibility. METHODS: Forty-nine eyes from 49 healthy normal subjects were studied. The anterior chamber angle was imaged with the Visante anterior segment OCT (Carl Zeiss Meditec, Dublin, CA) and the slit lamp OCT (SLOCT, Heidelberg Engineering, GmbH, Dossenheim, Germany) on one randomly selected eye in each subject and measured by two independent observers. The angle-opening distance (AOD 500), the trabecular-iris angle (TIA 500), and the trabecular-iris space area (TISA 500) at the nasal and temporal angles were measured. The agreements between SLOCT and Visante OCT measurements and the interobserver reproducibility were evaluated. RESULTS: The mean nasal/temporal anterior chamber angles measured by Visante OCT and SLOCT were 527 ± 249/572 ± 275 μm (AOD), 0.180 ± 0.091/0.193 ± 0.102 ² (TISA), and 38.1 ± 12.3/39.6 ± 13.2 degrees (TIA); and 534 ± 234/628 ± 254 μm (AOD), 0.191 ± 0.089/0.217 ± 0.093 ²(TISA), and 37.8 ± 10.1/40.6 ± 10.7 degrees (TIA), respectively. No significant difference was found between Visante OCT and SLOCT measurements except the temporal TISA (P = 0.034). The interobserver coefficient of variation ranged between 4.4% and 7.8% for Visante OCT and 4.9% and 7.0% for SLOCT. The spans of 95% limits of agreement of the nasal/temporal angle measurements between Visante OCT and SLOCT were 437/531 ², 0.174/0.186 ², and 25.3/28.0 degrees for AOD, TISA, and TIA, respectively. CONCLUSIONS: Although Visante OCT and SLOCT demonstrate high interobserver reproducibility for anterior chamber angle measurements, their agreement was poor.

Dr. C.K. Leung, Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Peoples Republic of China. tlims00@hotmail.com

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Classification:

6.9.2.1 Anterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)

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