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Abstract #21839 Published in IGR 10-3
Does peak intraocular pressure measured by water drinking test reflect peak circadian levels? A pilot study
Kumar RS; de Guzman MH; Ong PY; Goldberg IClinical and Experimental Ophthalmology 2008; 36: 312-315
See also comment(s) by Felipe Medeiros •
BACKGROUND: To determine whether there is a correlation between peak intraocular pressure (IOP) measured after water drinking test (WDT) and patient's peak daytime IOP. METHODS: Patients who were diagnosed with glaucoma, ocular hypertension and/or glaucoma-like discs were enrolled in this prospective observational pilot study. All subjects underwent daytime IOP measurement by a single observer using a Goldmann Applanation Tonometer at 3-h intervals. Subjects were then given 10 mL/kg body weight of water to drink over 5 min; IOP was measured every 15 min for an hour. Correlations between peak IOP and IOP fluctuations as measured by the two methods were analyzed using Pearson's correlation coefficient. RESULTS: Twenty-five patients were recruited for the study. There were 16 males and 9 females. The mean age was 68.8 ± 8.7 years (50-82 years), and 48% had primary open-angle glaucoma. The mean peak IOP measured by diurnal testing (15.52 ± 3.6 mmHg) was not statistically different from that measured by WDT (15.92 ± 3.2 mmHg) (P = 0.7). The mean fluctuation in IOP measured during the day (2.32 ± 1.3 mmHg) was also not significantly different from that measured by WDT (2.24 ± 1.2 mmHg) (P = 0.8). Though peak IOP measured during diurnal testing showed strong correlation with peak IOP during WDT (r = 0.876), IOP fluctuation measured by the two tests showed poor correlation (r = -0.0789). CONCLUSION: WDT may provide a satisfactory alternative measure of peak IOP in a clinic setting. A larger sample is required to assess whether it is a good measure of IOP fluctuation.
Dr. R.S. Kumar, Glaucoma Services, Sydney Hospital and Sydney Eye Hospital, Sydney, New South Wales, Australia
Classification:
6.13 Provocative tests (Part of: 6 Clinical examination methods)
6.1.2 Fluctuation, circadian rhythms (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
