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Abstract #21819 Published in IGR 10-3
Predicting response to glaucoma therapy in one eye based on response in the fellow eye: The monocular trial
Chaudhary O; Adelman RA; Shields MBArchives of Ophthalmology 2008; 126: 1216-1220
See also comment(s) by Tony Realini •
OBJECTIVE: To evaluate whether the change in intraocular pressure (IOP) observed in one eye after starting a glaucoma medication regimen is predictive of the change in IOP due to the same medication in the fellow eye. METHODS: A retrospective medical record review of 22 patients with primary open-angle glaucoma (POAG) and 27 glaucoma suspects who underwent monocular drug trials before the drug was added to the second eye. The absolute change in IOP from baseline and the relative change (change in treated eye minus change in fellow eye) in the first eye treated were compared with the second eye after binocular treatment. RESULTS: The absolute and relative decreases in IOP of the first eye were poorly correlated with those of the second eye in patients with POAG (r2< 0.001; P = .97 and r2 = 0.040; P = .38, respectively). However, they were well correlated in glaucoma suspects (r2 = 0.348; P = .001 and r2 = 0.396; P < .001, respectively). CONCLUSIONS: The change in IOP of one eye due to a medication may be predictive of the subsequent response of the fellow eye to the same medication in glaucoma suspects, but not in patients with POAG. Using the fellow eye as a control may confer a more accurate portrayal of the true therapeutic effects of a medicine, although further study is needed to support both of these findings.
Dr. O. Chaudhary, Department of Ophthalmology and Visual Science, Yale University School of Medicine, 40 Temple St, New Haven, CT 06510-2715, USA. Bruce.shields@yale.edu