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Abstract #26829 Published in IGR 12-3
Protective effect of Ginaton and fleabane on retinal ganglion cells
Wang M-L; Fei Z-G; Li H; He M-NInternational Journal of Ophthalmology 2010; 10: 850-852
AIM: To study the protective effect of Ginaton and fleabane on retinal ganglion cells in rabbit chronic high intraocular pressure model. METHODS: Chronic high intraocular pressure was created by injecting (alpha)-chymotrypsin(0.2mL) (2667.2(mu) kat) into rabbit posterior chamber. Thirty-two rabbits of successful model were divided randomly into four groups, with 8 rabbits in each group, and then treated with different therapies as follows; intragastric administration with Ginaton 150mg/kg, once a day (Ginaton group); intragastric administration with fleabane 150mg/kg, once a day (fleabane group); intragastric administration with Ginaton and fleabane (combination therapy group) and control group. After 4 weeks of treatment, all groups were checked retinal ganglion cells apoptosis, normal ganglion cells counting , pathological changes of retinal layers with light microscopy. RESULTS: Positive cells could be found in every group, the number of normal retinal ganglion cells was the largest in combination therapy group (889.00 (plus or minus) 40/mm(2)), the least in control group(581 (plus or minus) 24/mm(2)) , P<0.01. In light microscopy, the worst arrangement of retinal layers was in control group, and the best was in combination therapy group. CONCLUSION: Ginaton and fleabane could prevent high intraocular pressure caused apoptosis of retinal ganglion cells.LA: Chinese
H. Li. Department of Ophthalmology, University of South China, Hengyang 421001, Hunan Province, China. lihong5056@yahoo.com.cn
Classification:
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)
11.8 Neuroprotection (Part of: 11 Medical treatment)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
