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Abstract #12076 Published in IGR 7-1
Transient reduction of the ocular perfusion pressure and the oscillatory potentials of the ERG
Vadala M; Anastasi M; Lodato GVision Research 2005; 45: 1341-1348
PURPOSE: To evaluate the changes of the Oscillatory Potentials (OPs) of Electroretinogram (ERG) caused by short-term hypertension in human subjects, and their relationship with ocular perfusion pressure (OPP). METHODS: Suction cup technique in 12 normal volunteers with OPs simultaneously recording. RESULTS: Scotopic and photopic OPs were altered during OPP drop. Scotopic OPs showed more sensitiveness, with higher reduction (from 21% to 47%), when compared to the basal value, than in photopic recordings (from 14% to 34%). In both conditions, the relationship between OPP and OPs presented a steady amplitude before the trough after the +30 step, and rapid recovery after OPP normalisation. ANOVA and correlation analysis confirmed the data. CONCLUSION: The ERG OPs seemed to reflect the OPP modification. The features of OPs amplitudes suggest involvement of the retinal autoregulation mechanism and support development for further clinical studies.
Dr. M. Vadala, DINOOP, Unita di Oftalmologia, Universita di Palermo, Via Liborio Giuffre 13, 90127 Palermo, Italia
Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)