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Abstract #27064 Published in IGR 12-4
Change in outflow pathway of porcine eyes in vitro by nonpenetrating filtering surgery.
Xu W; Yao K; Wu W; Li Z; Ye PCanadian Journal of Ophthalmology 2010; 45: 1-5
Objective: To study the change in different outflow pathways of porcine eyes in vitro by nonpenetrating filtering surgery.Design: Experimental study.Participants: Sixty-four enucleated porcine eyes were studied.Methods: Deep sclerectomy was performed on isolated porcine eyes (Group 1A), then the superficial scleral flap was watertight sealed (Group 1B), and finally the oracles and the exterior wall of the Schlemm canal were watertight sealed (Group 1C). In another series of experiments, deep sclerectomy was performed with the scleral lake volume of 4 mm × 4 mm × 0.5 mm (Group 2A), 4 mm × 2 mm × 0.5 mm (Group 2B), and 4 mm × 1 mm × 0.5 mm (Group 2C), respectively; then the superficial scleral flap was watertight sealed. The control eye (Groups 1D and 2D) underwent creation and watertight sealing of a superficial scleral flap. Intraocular pressure (IOP) and outflow facility were determined preoperatively and postoperatively.Results: Compared with the preoperative value, IOP was decreased and outflow facility was increased in Groups 1A, 1B, and 1C (p < 0.05). In deep sclerectomy, the outflow facility was decreased by more than 0.18 µL/min/mm Hg after the conjunctival pathway was blocked. After the oracles and external wall of the Schlemm canal were blocked, the outflow facility decreased further by more than 0.09 µL/min/mm Hg but was still 0.06 µL/min/mm Hg higher than before surgery. There was a positive linear correlation between the deep sclerectomy volume and the ratio of IOP decrease or outflow facility increase postoperatively.Conclusions: Deep sclerectomy can increase the outflow of porcine eyes in vitro. The major factors maintaining the postoperative outflow increase include the subconjunctival pathway, the functional deep scleral lake, and the opening of the Schlemm canal.
Classification:
2.6.2.1 Trabecular meshwork (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics > 2.6.2 Outflow)
12.8.3 Non-perforating (Part of: 12 Surgical treatment > 12.8 Filtering surgery)
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
