advertisement
Abstract #23019 Published in IGR 11-1
Clinical research on visual electrophysiologic test in primary openangle glaucoma
Zhang X-M; Ma S-Q; Sun T-LInternational Journal of Ophthalmology 2009; 9: 64-66
AIM: To explore a new, effective, rapid, simple, and sensitive method for the early diagnosis of primary openangle glaucoma by applying visual electrophysiology. METHODS: Pattern electroretinogram (P-ERG), pattern reversal visual evoked potential (P-VEP) and oscillatory potentials (OPs) were tested on 60 glaucoma suspects (105 eyes) and 30 normal subjects (60 eyes) respectively. Grouping intervention was performed on the eyes with the above abnormal indexes: intervention group and control group. The intervention group (n = 34) local were performed local medication until IOP was reduced to 30% normal intraocular pressure. In control group (n = 32), the patients were not performed the guidance as aboved. Use statistics method to analyze the results. All the cases were followed up for 6-12 months. RESULTS: The amplitude of the pattern electroretinogram decreased and the latencies of wave peak of pattern electroretinogram were prolonged in all sixty glaucoma suspects. The total value of oscillatory potentials decreased in all sixty glaucoma suspects. The amplitude of the pattern reversal visual evoked potential decreased and the latencies of wave peak of pattern reversal visual evoked potential were prolonged in all sixty glaucoma suspects. The positive ratio was 57.1%, 33.3% and 47.6% respectively. Two positive out of the above mentioned three tests was 36.1%. The positive ratio of combined detection was 70.6%. Statistics analysis was conducted among every index after 6 months and the amplitude of the pattern electroretinogram showed significant difference. Statistics analysis was conducted among every index after 12 months and the total value of oscillatory potentials and the latencies of wave peak of pattern reversal visual evoked potential showed significant difference. CONCLUSION: The tests of P-ERG, P-VEP and OPs are of great clinical significance in the diagnosis of patients with suspect glaucoma. In all indexes, the amplitude of the pattern electroretinogram decreases, the latencies of wave peak of pattern electroretinogram, and the total value of oscillatory potentials are more sensitive. Visual electrophysiological examination can be used as a important means of the early diagnosis of primary open-angle glaucoma and can be used as an indicator of disease condition. LA: Chinese
Dr. X.-M. Zhang, Department of Ophthalmology, Liuzhou People's Hospital, Liuzhou 545001 Guangxi Zhuang, AR, China. zhangxm256@sohu.com
Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)