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Abstract #22406 Published in IGR 10-4
Vascular changes after intra-bleb injection of bevacizumab
Coote MA; Ruddle JB; Qin Q; Crowston JGJournal of Glaucoma 2008; 17: 517-518
See also comment(s) by Tina Wong •
PURPOSE: To illustrate changes in bleb vascularity after subconjunctival bevacizumab injection. METHODS: Longitudinal changes in bleb vascularity were followed over 6 months pre and postbevacizumab injection. RESULTS: Bleb vascularity associated with increased scarring activity was observed 10 days postcataract surgery in an eye that had undergone trabeculectomy 3 months previously. A single subconjunctival avastin injection led to a dramatic reduction in bleb vascularity for 6 weeks. With continued steroids, a diffuse, healthy, well functioning bleb with minimal scar tissue was present at 6 months. CONCLUSIONS: Subconjunctival injection of bevacizumab reduced bleb vascularity and may provide an adjunct to current antifibrosis therapy. Further studies to establish the effect of bevacizumab on postoperative scaring are warranted.
Dr. M.A. Coote, Centre for Eye Research Australia, University of Melbourne, Melbourne, Vic 8002, Australia