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Abstract #13546 Published in IGR 8-1
Comparison of the additive effects of nipradilol and carteolol to latanoprost in open-angle glaucoma
Haneda M; Shirato S; Maruyama K; Ohno YJapanese Journal of Ophthalmology 2006; 50: 33-37
PURPOSE: To compare the effects of nipradilol and carteolol on intraocular pressure (IOP) when added to latanoprost treatment for glaucoma patients. METHODS: Fifty patients with primary open-angle glaucoma were treated with latanoprost 0.005% once daily for 3 months. Then they were assigned to one of two groups randomly. One group received nipradilol 0.25% twice daily (nipradilol preceding group; n = 25), and the other carteolol hydrochloride 2% twice daily (carteolol preceding group; n = 25), for 3 months in addition to latanoprost. Then, nipradilol and carteolol were switched, and the subjects were treated for 3 more months. One eye was selected randomly for analysis. RESULTS: In the nipradilol preceding group, IOP was 21.4 ± 2.3 mmHg (mean ± SD) at baseline, and 16.8 ± 1.9 mmHg at the end of latanoprost monotherapy (P < 0.01). The addition of nipradilol decreased IOP to 15.8 ± 1.7 mmHg, and the change to carteolol, to 15.3 ± 2.0 mmHg. In the carteolol preceding group, IOP was 21.2 ± 2.0 mmHg at baseline, and 17.0 ± 2.1 mmHg at the end of latanoprost monotherapy (P < 0.01). The addition of carteolol decreased IOP to 15.4 ± 1.8 mmHg, and the change to nipradilol, to 16.3 ± 1.9 mmHg. Additional IOP reduction was greater with carteolol than with nipradilol (cross-over analysis of variance; P = 0.0005). CONCLUSIONS: Both nipradilol and carteolol have additive effects when used in combination with latanoprost. Carteolol, however, may have a more potent effect than nipradilol.
Dr. M. Haneda, Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan, haneda-oph@umin.ac.jp
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.4 Prostaglandins (Part of: 11 Medical treatment)
