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Abstract #17176 Published in IGR 9-1
Effect of switching from aqueous timolol to gel-forming timolol ophthalmic solution
Inoue K; Sogabe M; Wakakura M; Inouye J; Tomita GJapanese Journal of Clinical Ophthalmology 2006; 60: 1971-1976
PURPOSE: To compare the effect of gel-forming timolol solution switched from aqueous timolol. CASES AND METHOD: This study was made on 103 eyes of 103 patients who were using 0.5% aqueous timolol for glaucoma or ocular hypertension. The ages ranged from 33 to 84 years, average 66 years. They were given 0.5% gel-forming timolol solution as substitute for aqueous timolol. Intraocular pressure (IOP) was measured once a month for 3 months. They were then asked about the subjective evaluation and preferences. RESULTS: IOP averaged 16.6 ± 2.6 mmHg before and 15.7 to 15.9 mmHg after switching. The difference was significant (p < 0.0001). Irritability was reported during use of aqueous timolol and stickiness and irritable feeling during gel-forming timolol. Aqueous timolol was preferred by 11 and gel-forming timolol by 62 patients. CONCLUSION: Gel-forming timolol solution has hypotensive effect similar to aqueous timolol. Many patients prefer the former due to its convenience. LA: Japanese
Dr. K. Inoue, Inouye Eye Hospital, 4-3 Kanda-Surugadai, Tokyo 101-0062, Japan.
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
