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Abstract #14051 Published in IGR 8-3
Abnormal flow-mediated vasodilation in normal-tension glaucoma using a noninvasive determination for peripheral endothelial dysfunction
Su WW; Cheng ST; Hsu TS; Ho WJInvestigative Ophthalmology and Visual Science 2006; 47: 3390-3394
See also comment(s) by Selim Orgül •
PURPOSE: To assess peripheral vascular endothelial function in patients with normal-tension glaucoma (NTG) by using a noninvasive METHOD: endothelium-dependent flow-mediated vasodilation (FMD). METHODS: Forty patients with NTG and 40 healthy age- and sex-matched normal control subjects underwent measurement of FMD and endothelium-independent nitroglycerin-mediated vasodilation (NMD) via high-resolution, two-dimensional (2D) ultrasonographic imaging of the brachial artery. The patients also underwent blood sampling for biochemistry, lipid profile, and high-sensitivity C-reactive protein (hsCRP) analysis. RESULTS: The NTG group exhibited significant impairment of FMD compared with the control group (NTG: 2.64% ± 2.22%, control: 5.96% ± 2.50%, P < 0.001). Multivariate analysis demonstrated that the presence of NTG was the strongest independent predictor of FMD. The lipid profile and hsCRP did not differ significantly between the two groups. CONCLUSIONS: This study demonstrated impaired FMD in patients with NTG and the results provide evidence of a generalized peripheral vascular endothelial dysfunction in patients with NTG.
Dr. W.W. Su, Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Tao-Yuan, Taiwan
Classification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
