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Miscellaneous (6)

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Abstract #20949 Published in IGR 10-2

Orbital fat atrophy in glaucoma patients treated with topical bimatoprost - can bimatoprost cause enophthalmos?

Tappeiner C; Perren B; Iliev ME; Frueh BE; Goldblum D
Klinische Monatsblätter für Augenheilkunde 2008; 225: 443-445

See also comment(s) by Andreas Boehm •

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PURPOSE: The aim of this communication is to report enophthalmos as a possible new adverse effect of topical bimatoprost treatment. PATIENTS AND METHODS: A retrospective case series of five glaucoma patients under long-term topical bimatoprost treatment was evaluated. Documentation with photo and Hertel exophthalmometry was reviewed. RESULTS: In all five patients a deep lid sulcus, reduced infraocular fat pads and enophthalmos-suspicious Hertel values were found (mean 11.9 mm; SD 2.4). Other aetiologies for enophthalmos were excluded anamnestically and by clinical examination. CONCLUSION: Bimatoprost may lead to an alteration of the eyelid with deepening of the lid sulcus and may also be responsible for an iatrogenic orbital fat atrophy. A possible mechanism of action might be the induction of apoptosis of orbital fibroblasts with a remodelling of the extracellular matrix. Prospective studies are necessary to confirm this cross-sectional observation. LA: German.

Dr. C. Tappeiner, Klinik und Poliklinik für Augenheilkunde, Inselspital, Universität Bern, Switzerland

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Classification:

11.4 Prostaglandins (Part of: 11 Medical treatment)

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