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Abstract #46194 Published in IGR 13-2
Comparison of axial lengths in occludable angle and angle-closure glaucoma--the Bhaktapur Glaucoma Study
Thapa SS; Paudyal I; Khanal S; Paudel N; van Rens GHOptometry and Vision Science 2011; 88: 150-154
To compare the anterior chamber depth (ACD) and axial length of eyes in a population-based sample among normal, occludable angle, and primary angle-closure glaucoma (PACG) groups. Totally, 3979 subjects from a population-based glaucoma prevalence study underwent complete ocular examination including four mirror gonioscopy. An angle in which >270 degrees of the posterior trabecular meshwork could not be seen was considered occludable. PACG was considered when there were features of primary angle closure (eye with an occludable angle, peripheral anterior synechiae, increased intraocular pressure, iris whorling, lens opacities, or excessive pigment deposition on the trabecular surface) and optic disc with glaucomatous damage. A handheld ultrasonic biometer was used to measure the ACD and the axial length of subjects. The ACD and axial length were measured on all subjects with occludable angles (n = 86), PACG (n = 17) and a random subgroup of normal subjects (n = 685). The measurements were compared among the groups and statistically analyzed using independent t-test, one-way analysis of variance, (chi)2 test, and logistic regression. The mean age among occludable angle and angle-closure glaucoma groups was 59.64 (plus or minus) 9.70 and 71.23 (plus or minus) 8.5 years, respectively, which was significantly higher (p < 0.001) than the mean of 54.03 (plus or minus) 10.90 years among normal subjects. In the occludable angle group, the ACD (2.55 (plus or minus) 0.69) was significantly different (p < 0.001) than the normal group (2.85 (plus or minus) 0.39). The axial length (22.08 (plus or minus) 0.83) in the occludable angle group was also considerably different (p < 0.001) when compared with the normal group (22.62 (plus or minus) 0.90). In PACG group, the ACD and axial length were 2.48 (plus or minus) 0.22 and 22.02 (plus or minus) 0.59, respectively. The risk of having an occludable angle decreased with per unit millimeter increase in ACD (odds ratio, 0.24; 95% confidence intervals, 0.12-0.50) and axial length (odds ratio, 0.49; 95% confidence intervals, 0.36-0.67) after adjusting the effect of age and sex. The eyes in Nepalese population with occludable angle and angle-closure glaucoma appear to have significantly shallower anterior chambers and shorter axial lengths when compared with the normal group.
S.S. Thapa. Nepal Glaucoma Eye Clinic, Tilganga Institute of Ophthalmology, Kathmandu, Nepal. Email: ssthapa@tilganga.com.np
Classification:
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
9.3.4 Primary angle closure suspect (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
6.12 Ultrasonography and ultrasound biomicroscopy (Part of: 6 Clinical examination methods)