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Abstract #25993 Published in IGR 12-2
Evaluation of the biocompatibility of novel peptide hydrogel in rabbit eye
Liang L; Xu X-D; Chen C-S; Fang J-H; Jiang F-G; Zhang X-Z; Zhuo R-XJournal of Biomedical Materials Research - Part B Applied Biomaterials 2010; 93: 324-332
A peptide containing a RGD (arginine-glycine-aspartic acid) sequence as well as a hydrophobic N-fluorenyl-9-methoxycarbonyl (FMOC) tail was prepared via a standard FMOC solid-phase peptide synthesis technique. The supramolecular self-assembly of such peptide through (pi)-(pi) stacking from FMOC tail can transfer the peptide aqueous solution into a three-dimensional hydrogel. The biocompatibility of the peptide hydrogel was evaluated via clinical follow-up and histological analysis. The data obtained demonstrated that the peptide hydrogel exhibited good biocompatibility when injected to the subconjunctival space and anterior chamber of rabbit, indicating a potential application in ophthalmology as an implantable drug delivery system for the treatment to ocular anterior segment diseases such as glaucoma, iridocyclitis, and keratopathy.
F.-G. Jiang. Department of Ophthalmology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. fgjiang@hotmail.com
Classification:
11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
