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Editors Selection IGR 7-1
Examination methods: Retinal nerve fibre layer thickness
Comment by Tetsuya Yamamoto on:
13791 Peripapillary retinal nerve fiber layer thickness variations with myopia, Hoh ST; Lim MC; Seah SK et al., Ophthalmology, 2006; 113: 773-777
13599 Analysis of the thickness of the retinal nerve fiber layer of myopic eyes, Xu Y-E; Wu X-Y; Liu S-Z et al., International Journal of Ophthalmology, 2006; 6: 116-118
This cross sectional study by Xu et al. (327) deals with the relationship between the degree of myopia and RNFL thickness. Myopia is much prevalent in Asia, especially in Chinese and as you can easily imagine, it is quite difficult to evaluate glaucomatous change in optic nerve head and RNFL in myopic eyes. Thus, the potential importance of this paper is so great. The authors used GDx VCC to evaluate the RNFL thickness and studied a total of 166 eyes of emmetropic or myopic, but otherwise healthy subjects. They concluded that the RNFL thickness becomes thinner in the superior 120 degree area with increasing myopia and the circumferential variability of RNFL thickness increases similarly. When we compare the result of the present study with that of Kremmer et al. (Graefes Arch Clin Exp Ophthalmol 2004; 242:489), where scanning laser polarimetry was also used, both studies pointed out the refractive error-dependent RNFL thinning.
RNFL thinning is refractive error dependentIn another study by Hoh et al. (326), which employed OCT in young myopic Asians (mostly Chinese), however, they did not find any correlations between mean peripapillary RNFL thickness and spherical equivalent or axial length. Because the methodology employed is quite different among these studies, we need to elucidate whether there is a correlation between RNFL thickness and myopia. This is important, because the establishment of RNFL thickness in normals is fundamental to the evaluation of the glaucomatous optic neuropathy.
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