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Editors Selection IGR 8-1
Neuroprotection: NSAIDs and latanoprost
Comment by Thom Zimmerman on:
13446 Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost in patients with primary open angle glaucoma or ocular hypertension, Chiba T; Kashiwagi K; Chiba N et al., British Journal of Ophthalmology, 2006; 90: 314-317
13415 Nimesulide oral administration increases the intraocular pressure-lowering effect of latanoprost in patients with primary open-angle glaucoma, Costagliola C; Parmeggiani F; Caccavale A et al., American Journal of Ophthalmology, 2006; 141: 379-381
Two interesting papers, by Chiba et al. (190) and by Costagliola et al. (192) show differing effects of a nonsteroidal anti-inflamatory drug (NSAID) on latanoprost's hypotensive effect. Carl Camras and Albert Alm, the most knowledgeable scientists concerning the clinical effects of latanoprost have both recently written editorials1,2 on this subject, the interaction of NSAIDs and latanoprost, and I refer you to them. That being said, let's look at the two papers at hand. The scientists from Japan found a decrease in latanoprost's hypotensive effect when an NSAID ophthalmic solution was added to the latanoprost-treated eye. The scientists from Italy, who have studied this interaction before,3 found the opposite. Examining these works, short comings appear (as in most clinical studies that examine basic mechanism.1 Of the numerous studies that have been done on this interaction, the clinical effect whether increased or decreased is thought to be negligible and of little clinical significance.2 Besides, this would be handled in the clinic on an individual basis. These studies are not comparable for a number of reasons: dose, route, follow-up, etc. Both had small numbers (16 patients in each study) and must be added to the list of studies on this subject as described by Camras in the last sentence of his aforementioned editorial.
References
- Alm A: Can NSAIDs and prostaglandin analogues be combined? B J Ophthalmol 2006; 90: 259-260.
- Camras C: Comment in Editors’ Selection. International Glaucoma Review 2006; 7: 379.
- Costagliola C, Parmeggiani F, et al: The influence of d. ophthalmic solution on the intracocular pressure-lowering effect of topical 0.5% timolol and 0.005% latanoprost in primary open-angle glaucoma patients. Exp Eye Res 2005; 81: 610-615.
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