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Editors Selection IGR 7-1
Examination methods: CCT
Comment by Peter Shah on:
11819 Central corneal thickness and thickness of the lamina cribrosa in human eyes, Jonas JB; Holbach L, Investigative Ophthalmology and Visual Science, 2005; 46: 1275-1279
Mean central corneal thickness (CCT) of 616.6 ± 108.3 micrometres and mean central lamina cribrosa thickness (LCT) 378.1 ± 117.8 micrometres were statistically independent of each otherJonas and Holbach (32) published an excellent and highly recommended histomorphometric study evaluating the relationship between central corneal thickness and lamina cribrosa thickness in enucleated nonglaucomatous human eyes. All eyes had been removed because of malignant choroidal melanoma. All globes were sectioned one week after fixing and histomorphometric measurements were made on light microscopy. Mean central corneal thickness (CCT) of 616.6 &plm; 108.3 micrometres and mean central lamina cribrosa thickness (LCT) 378.1 &plm; 117.8 micrometres were statistically independent of each other. The study showed that CCT did not correlate significantly with LCT, peripapillary scleral thickness or shortest distance between the intraocular space and cerebrospinal fluid space. The authors critically discuss sources of measurement error and potential bias with respect to histologic artefact and sectioning methods. The authors then proceed to provide a detailed account of the differences in embryological development which may support the lack of association between CCT and LCT - this is the highlight of the paper. This is an important addition to the literature concerning possible biomorphometric associations in glaucoma pathogenesis.
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