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Editors Selection IGR 9-4

Angle-closure glaucoma: ACD and systemic relationships

Comment by David Friedman on:

20913 Anterior chamber depth and chamber angle and their associations with ocular and general parameters: The Beijing Eye Study, Xu L; Cao WF; Wang YX et al., American Journal of Ophthalmology, 2008; 145: 929-936

Find related abstracts

Xu et al. (501) have published a paper on ocular and systemic relationships of anterior chamber depth (ACD) and anterior chamber angle width (ACA) from a population-based study of Chinese persons from Beijing examined in 2006. ACD and ACA were measured using the Heidelberg slit lamp anterior segment optical coherence tomography (OCT) device. The authors report that ACD and ACA were strongly correlated (R = 0.76), and that both parameters were smaller with increasing age, more hyperopic refractive error, female gender, shorter stature and lower body weight, increased nuclear cataract (as graded from lens photographs), and larger optic disc size. Shallower ACD (and not angle width) was also associated with a thicker cornea and arterial hypertension. This study, using OCT technology, confirms findings that have been published since the 1950s using gonioscopy and optical ACD measurements. The finding of an independent association of stature and body weight with ACA is new and worth further assessment in other populations. The association of ACD with hypertension is not easily explained and may be spurious. In summary, this is a well conducted study that confirms that angle closure is strongly associated with ACD and that these parameters are associated with (and largely determined by) the size of various eye components.

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