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The paper by Garaci et al. (1347) is an excellent resource for understanding principles of novel neuroimaging techniques, and discusses their application to the study of glaucoma. Based on neuropathological studies in experimental non-human primate glaucoma1 and human glaucoma,2 neuroradiologic findings may be expected in vision pathways in patients with glaucoma. Atrophy of the lateral geniculate nucleus has been recently described in human glaucoma by conventional MRI.3
To be able to apply novel neuroimaging techniques to larger glaucoma populations, normative neuro-imaging databases, accounting also for age, are neededTechnological advances such as diffusion tensor and functional MRI may also be powerful research tools to assess visual pathways in glaucoma, and in fact, reduced visual cortical activity4 has been detected in patients. In both of these human studies, patients with specific patterns of visual field defects were evaluated. To be able to apply these approaches to larger glaucoma populations, normative neuro-imaging databases, accounting also for age, are needed.
Our understanding of glaucomatous disease, its progression and the effects of novel treatment strategies will continue to advance as multidisciplinary research teams with state-of-the-art neuro-imaging technology and expertise come together.